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HPE ProLiant DL380 Gen11 vs Gen12 Comparison - What’s the Difference?

The HPE ProLiant DL380 series has long been a staple in enterprise environments, known for its reliability, scalability, and performance. With the introduction of the HPE ProLiant Compute DL380 Gen12, IT professionals are now faced with an important question: how does it compare to the DL380 Gen11?


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HPE ProLiant DL380 Gen11 vs Gen12 Comparison - What's the Difference?


The HPE ProLiant Compute DL380 Gen12 improves on the Gen11 with next-gen Intel Xeon processors, higher memory bandwidth, and PCIe 5.0 support for faster storage and GPU performance. It also features better power efficiency, enhanced security, and improved remote management, making it a stronger choice for modern AI, cloud, and HPC workloads.


A detailed comparison of the HPE ProLiant DL380 Gen11 vs. Gen12 servers, highlighting key upgrades in processor performance, memory bandwidth, PCIe 5.0 support, AI and HPC workload optimization, NVMe storage capacity, Compute Express Link (CXL) expansion, and power efficiency improvements. The HPE ProLiant Compute DL380 Gen12 features Intel Xeon 6th Gen Scalable processors with up to 144 cores, 6400MT/s DDR5 memory, NVMe over Fabrics (NVMeoF) support, and enhanced liquid cooling, making it a top choice for enterprise, cloud, and high-performance computing (HPC) environments.

 

HPE ProLiant DL380 Gen11 vs Gen12: Core Architecture and Processor Support

Feature

DL380 Gen11

DL380 Gen12

Processor Family

Intel Xeon 4th & 5th Gen Scalable

Intel Xeon 6th Gen Scalable

Max Core Count per CPU

64 cores

144 cores

Max Processor TDP

350W

400W

PCIe Version

PCIe 5.0

PCIe 5.0 (Gen5)

Memory Channels

8

12

Max Cache per CPU

112.5MB

180MB

NUMA Nodes per CPU

4

6

Key Differences between HPE ProLiant DL380 Gen11 and Gen12

  • Gen12 introduces support for Intel Xeon 6th Gen processors, bringing significant performance and efficiency improvements, particularly for AI and HPC workloads.

  • Higher cache allocation allows for improved processing efficiency and reduced latency.

  • Increased NUMA nodes improve multi-threaded application performance and workload distribution.

  • Higher power draw per CPU (TDP), requiring optimized thermal management solutions.


 

HPE ProLiant DL380 Gen11 vs Gen12: Memory Performance and Capacity

Feature

DL380 Gen11

DL380 Gen12

Memory Type

DDR5

DDR5

Max Memory Speed

5600MT/s

6400MT/s

Max Memory Capacity

8TB

8TB

Memory Slots

32 DIMM

32 DIMM

RDIMM/LRDIMM Support

Yes

Yes

Persistent Memory Support

Intel Optane PMem 200 Series

No (Replaced by CXL Memory Expansion)

Memory Bandwidth per CPU

Up to 460GB/s

Up to 640GB/s

Key Differences between HPE ProLiant DL380 Gen11 and Gen12

  • Gen12 increases max memory capacity to 8TB using CXL-based memory expansion, eliminating traditional Optane Persistent Memory support.

  • Enhanced memory bandwidth, allowing for better performance in memory-intensive applications such as AI/ML workloads.


 

HPE ProLiant DL380 Gen11 vs Gen12: Storage and Expandability

Feature

DL380 Gen11

DL380 Gen12

Drive Bays

12LFF / 24SFF / 36 EDSFF

12LFF / 24SFF / 36 EDSFF

Max Storage Capacity

~550TB+ (NVMe)

~600TB+ (NVMe)

NVMe Support

PCIe Gen5 NVMe

PCIe Gen5 NVMe

RAID Controllers

HPE Smart Array MR / SR

HPE Smart Array MR / SR

CXL Storage Support

No

Yes

Storage Fabric Support

No

NVMeoF, RDMA

Key Differences between HPE ProLiant DL380 Gen11 and Gen12

  • Gen12 adds Compute Express Link (CXL) storage support, allowing for direct CPU-to-storage access without traditional bottlenecks.

  • Introduction of NVMe over Fabrics (NVMeoF) and RDMA for high-speed networking storage solutions.


 

HPE ProLiant DL380 Gen11 vs Gen12: Connectivity and Expansion

Feature

DL380 Gen11

DL380 Gen12

PCIe Slots

Up to 8x PCIe 5.0

6 PCIe 5.0 + 2 OCP 3.0

Networking

OCP 3.0 slots

OCP 3.0 slots

Max GPUs Supported

8 single-wide or 3 double-wide

8 single-wide or 3 double-wide

USB Ports

USB 3.2 Gen1 (multiple)

USB 3.2 Gen1 (multiple)

NVLink Support

No

Yes

RDMA Networking

No

Yes

Key Differences between HPE ProLiant DL380 Gen11 and Gen12

  • Gen12 introduces NVLink and RDMA support, enabling faster GPU communication and low-latency networking for AI and HPC workloads.

  • Same PCIe 5.0 slots and OCP 3.0 networking, but Gen12 optimizes expansion lanes for improved high-speed connectivity.


 

HPE ProLiant DL380 Gen11 vs Gen12: Power and Cooling

Feature

DL380 Gen11

DL380 Gen12

Power Supply Options

800W - 2200W

800W - 3000W

Cooling System

Air-cooled / Liquid-cooled (optional)

Air-cooled / Liquid-cooled (optimized)

Fan Redundancy

Yes

Yes

Dynamic Power Scaling

No

Yes

Key Differences between HPE ProLiant DL380 Gen11 and Gen12

  • Dynamic power scaling introduced in Gen12, allowing the system to optimize power consumption dynamically based on workload requirements.

  • Enhanced liquid cooling, optimized for high-performance compute tasks, reducing thermal throttling risks.


 

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