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HPE ProLiant Compute Gen12 Servers: New Features Explained & Model Comparison

HPE’s ProLiant Compute Gen12 servers have arrived, bringing new capabilities, architectural changes, and performance improvements. But does it always make sense to upgrade?


HPE ProLiant Servers & Server Parts: Save up to 80%

While Gen12 introduces Intel Xeon 6 processors, Direct Liquid Cooling (DLC), and improved security, Gen11 servers remain a solid choice for many workloads.


HPE ProLiant Gen12 vs. Gen11 server comparison with Intel Xeon 6 processors, DDR5 memory up to 8TB, PCIe Gen5 NVMe storage, Direct Liquid Cooling (DLC), and enhanced security. Covers DL320, DL340, DL360, DL380, DL380a, ML350, DL580, and Synergy 480 models for AI, HPC, virtualization, and enterprise workloads. Server-parts.eu.

 

What’s New in HPE ProLiant Compute Gen12?


CPU Architecture: Intel Xeon 6 P-Core - HPE ProLiant Compute Gen12


✔️ Up to 144 cores per CPU (vs. 60 cores max in Gen11).

✔️ Higher memory bandwidth: DDR5 up to 6400MT/s (vs. 5600MT/s in Gen11).

✔️ Power-efficient architecture: Claims up to 65% power savings annually.

✔️ Optimized for AI, edge computing, and data analytics workloads.


If you need high-core workloads, Gen12 is a strong contender, but Gen11 remains powerful for standard enterprise applications.

 

Memory & Storage Enhancements - HPE ProLiant Compute Gen12


DDR5 up to 8TB (vs. 4TB in Gen11).

EDSFF storage support, allowing up to 36 drives in a 2U chassis.

More NVMe storage bays with PCIe Gen5 SSDs.


Gen12 offers better memory scaling and storage flexibility, but Gen11 remains viable for general enterprise storage needs.

 

Cooling: Direct Liquid Cooling (DLC) - HPE ProLiant Compute Gen12


💧 DLC now available across more models, reducing cooling power consumption by up to 90%.

🌬️ Gen11 primarily used air cooling, with limited DLC models.


If power efficiency and heat management are priorities, Gen12’s DLC option is a game-changer.

 

Security & Compute Ops Management - HPE ProLiant Compute Gen12


🔐 iLO 7 with Secure Enclave Technology for enhanced firmware protection.

🛡️ Quantum Computing Resistance for future-proof cryptographic security.

📊 HPE Compute Ops Management (COM) for AI-driven automation.


If security compliance is a concern, Gen12’s security features provide extra value.

 

HPE ProLiant Compute Gen12 Server Lineup Comparison


Single-Socket HPE ProLiant Compute Gen12 Servers

Model

Form Factor

CPU

Max Memory

Max Storage

GPU Support

Cooling Options

DL320 Gen12

1U Rack

1x Intel Xeon 6

2TB DDR5

20x EDSFF, 8x SFF, 4x/10x/12x LFF

4 SW / 2 DW GPUs

Air, Liquid, DLC

DL340 Gen12

2U Rack

1x Intel Xeon 6

4TB DDR5

20x EDSFF, 8x SFF, 12x LFF

6 SW / 4 DW GPUs

Air, Liquid, DLC


📌 Best for: Cost-efficient hybrid cloud, virtualization, and edge computing.


 

Dual-Socket HPE ProLiant Compute Gen12 Servers

Model

Form Factor

CPU

Max Memory

Max Storage

GPU Support

Cooling Options

DL360 Gen12

1U Rack

2x Intel Xeon 6

8TB DDR5

20x EDSFF, 10x SFF, 4x LFF

3 SW GPUs

Air, Liquid, DLC

DL380 Gen12

2U Rack

2x Intel Xeon 6

8TB DDR5

36x EDSFF, 24x SFF, 12x LFF

8 SW / 3 DW GPUs

Air, Liquid, DLC

DL380a Gen12

4U Rack

2x Intel Xeon 6

4TB DDR5

16x EDSFF, 8x SFF

16 SW / 8 DW GPUs

DLC Only


📌 Best for: AI/ML workloads, large-scale virtualization, and GPU acceleration.


 

Specialized HPE ProLiant Compute Gen12 Models

Model

Form Factor

CPU

Max Memory

Max Storage

Use Case

ML350 Gen12

Tower

2x Intel Xeon 6

8TB DDR5

12 LFF / 24 SFF

SMB/Edge Computing

DL580 Gen12

4U Rack

4x Intel Xeon 6

TBD

TBD

High-Density Compute

Synergy 480 Gen12

Blade

2x Intel Xeon 6

TBD

TBD

Cloud/Enterprise Blade


📌 Best for: Enterprise data centers, modular compute environments, and AI-driven cloud solutions.


 

Does It Make Sense to Upgrade to HPE ProLiant Compute Gen12?


When to Choose Gen12:

AI, HPC, and Cloud Workloads – Need higher core density, better cooling, and PCIe Gen5.

Extreme GPU Acceleration – Supports up to 16 GPUs in DL380a.

Energy Efficiency Priority – DLC saves power in high-density data centers.

Security-First Environments – Quantum resistance and enhanced firmware protection.


 

When Gen11 is Still a Good Choice:

Virtualization & General Enterprise Workloads – No major performance gap.

Budget-Constrained Environments – Gen11 offers similar power at a lower price.

Storage-Centric Workloads – Gen11 has great NVMe and SAS support.

SMBs & Standard Data Centers – No need for extreme AI acceleration.


HPE ProLiant Compute Gen12 brings key upgrades, but Gen11 remains a cost-effective and reliable choice. Upgrade for AI, efficiency, and security; stick with Gen11 for budget-friendly enterprise IT.

 

HPE ProLiant Servers & Server Parts: Save up to 80%

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